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This book traces the history of adenosine receptor research from molecular biology to medicinal chemistry to behavior, including their implications in disease and potential strategies as therapeutic targets. It provides the reader with a comprehensive overview of the adenosine receptors that includes information on all subtypes - A1, A2A, A2B and A3. Aspects addressed include the most up to date information on their functional distribution in the nervous and peripheral systems, behavioral roles in inflammation, cancer, pain and neurological diseases such as Huntington’s disease, Epilepsy, Parkinson’s disease and Alzheimer’s disease.
Adenosine --- Receptors. --- Adenocard --- Adenoscan --- Purine nucleosides --- Ribonucleosides --- Neurochemistry. --- Biochemistry --- Neurosciences
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Animal biochemistry --- Adenosine --- Adenocard --- Adenoscan --- Purine nucleosides --- Ribonucleosides --- Receptors
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Ribavirin --- Ribonucleosides --- Virus Diseases --- therapeutic use --- drug therapy
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Adenosine --- Nervous system --- Receptors. --- Degeneration --- Molecular aspects. --- Organs (Anatomy) --- Neurosciences --- Adenocard --- Adenoscan --- Purine nucleosides --- Ribonucleosides
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Ribavirin --- Virus diseases --- Antiviral Agents --- Ribavirin --- Ribonucleosides --- Virus Diseases --- Congresses --- Chemotherapy --- Congresses --- therapeutic use --- therapeutic use --- drug therapy
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Homeostasis of key metabolites and metabolic health affects all bodily systems. Not surprisingly, altered metabolic function is associated with a wide spectrum of dysfunctions in the central nervous system – including developmental disorders, acute nervous system injury, and neurodegenerative disorders. Accordingly, metabolism-based therapies offer significant promise as new category of treatment options designed to limit, delay or reverse the disease process by reconstructing homeostatic functions. Increasingly it is appreciated that restoring metabolic health could promote normal nervous system activity, and improve behavior and cognition. Adenosine: A Key Link Between Metabolism and Central Nervous System Activity focusses on diverse aspects of adenosine, an evolutionarily conserved homeostatic bioenergetic regulator in the central nervous system. Because of its interrelationship with ATP (adenosine triphosphate), adenosine is integral to cell metabolism. At the same time, adenosine influences neuronal activity directly via receptors, and is involved in biochemical processes related to gene expression. Thus, adenosine is uniquely placed as a reciprocal and rapid link between changes in metabolism and changes in neuronal activity, and, on a longer time scale, to changes in gene expression and long term changes in cell function. Leaders in the field feature basic research on adenosine at the cellular level in the central nervous system, and relate these findings to its recognized potential in diverse acute and chronic disorders. This comprehensive overview of adenosine also highlights emerging adenosine-based treatments and associated opportunities for central nervous system disorders.
Adenosine. --- Biochemistry. --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Adenocard --- Adenoscan --- Composition --- Medicine. --- Neurosciences. --- Neurobiology. --- Biomedicine. --- Biology --- Chemistry --- Medical sciences --- Purine nucleosides --- Ribonucleosides
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This book is the first definitive overview on adenosine receptor antagonists and their application to the treatment of Parkinson's Disease. The effect of these novel non-dopamine drugs on vitro and in vivo systems clearly shows their potential for the treatment of this debilitating disease. This book covers how the Parkinson's disease antagonist drug, A2A, has been researched, developed, and tested. It is an essential book for researchers interested in the basal ganglia, purine biology, and Parkinson's Disease.Key Features* Discusses the discovery and development of a
Adenosine. --- Parkinson's disease --- Palsy, Shaking --- Paralysis agitans --- Parkinson disease --- Parkinsonism --- Shaking palsy --- Brain --- Extrapyramidal disorders --- Adenocard --- Adenoscan --- Purine nucleosides --- Ribonucleosides --- Treatment. --- Diseases
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Antiviral agents --- Ribonucleosides --- Congresses --- congresses --- Antiviral Agents --- Ribavirin --- Antiviral Drugs --- Antivirals --- Agents, Antiviral --- Drugs, Antiviral --- Interferon Inducers --- Virus Diseases --- Viruses --- Virus Inactivation --- Conferences - Meetings --- ICN-1229 --- Rebetol --- Ribamide --- Ribamidil --- Ribamidyl --- Ribasphere --- Vilona --- Viramide --- Virazide --- Virazole --- Ribovirin --- Tribavirin --- ICN 1229 --- ICN1229 --- Virus diseases --- Viral diseases --- Viral infections --- Virus infections --- Communicable diseases --- Medical virology --- Pathogenic viruses --- Ribofuranosyltriazolecarboxamide --- Amides --- Antimetabolites --- Nucleosides --- Triazoles --- Testing&delete& --- Chemotherapy&delete& --- Congresses. --- congresses. --- Antiviral --- Antiviral Agent --- Antiviral Drug --- Agent, Antiviral --- Drug, Antiviral --- Testing --- Chemotherapy
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Adenylic acid --- Adenosine --- Adenine nucleotides --- Neurotransmitters --- Physiological effect --- Testing --- Congresses --- -Adenosine --- -Adenylic acid --- -Neurotransmitters --- #Lilly --- Chemical nerve transmitters --- Nerve transmitter substances --- Neural transmitters --- Neurohumors --- Neuroregulators --- Synaptic transmitters --- Transmitters, Chemical nerve --- Transmitters, Synaptic --- Neurochemistry --- Neural transmission --- Adenine ribonucleotide --- Adenine-ribose phosphate --- Adenosine monophosphate --- Adenosine phosphate --- Adenosine phosphoric acid --- AMP (Biochemistry) --- Adenine --- Adenine nucleoside phosphates --- Adenosine phosphates --- Purine nucleotides --- Adenocard --- Adenoscan --- Purine nucleosides --- Ribonucleosides --- Adenylic acid - Physiological effect --- Adenosine - Physiological effect --- Adenosine - Testing --- Adenine nucleotides - Congresses --- Adenosine pharmacology --- Adenosine physiology
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Nutrient Metabolism, Second Edition, provides a comprehensive overview of the supply and use of nutrients in the human body and how the body regulates intake. Chapters detail the principles determining digestion and absorption of food ingredients and how these compounds and their metabolites get into the brain, cross the placenta and pass through the kidneys. Each nutrient's coverage contains a nutritional summary that describes its function, its food sources, dietary requirements, potential health risks if deficient, and impact of excessive intake. This handbook contains the latest informati
Metabolism. --- Metabolism and nutrition. --- Adenosine -- Metabolism. --- Molecular biology. --- Metabolic Phenomena --- Food --- Physiological Phenomena --- Growth Substances --- Physiological Effects of Drugs --- Food and Beverages --- Phenomena and Processes --- Technology, Industry, Agriculture --- Pharmacologic Actions --- Chemical Actions and Uses --- Chemicals and Drugs --- Micronutrients --- Metabolism --- Nutritional Physiological Phenomena --- Human Anatomy & Physiology --- Health & Biological Sciences --- Physiology --- Adenosine --- Molecular biochemistry --- Molecular biophysics --- Biochemistry --- Biophysics --- Biomolecules --- Systems biology --- Adenocard --- Adenoscan --- Purine nucleosides --- Ribonucleosides --- Anabolism --- Catabolism --- Metabolism, Primary --- Primary metabolism
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